Research progress on drugs for the treatment of COVID-19

At present, coronavirus disease-19 (COVID-19) caused by novel coronavirus (SARS-CoV-2) has been spreading around the world, but no specific therapeutic drug or vaccine has been developed for the virus. By collecting the latest literature and searching related database websites, the biological characteristics and main targets of SARS-CoV-2, the clinical therapeu tic drugs and the latest drug research were reviewed to provide information for clinical treatment and provide reference for the research and development of new drugs against SARS-CoV-2.Copyright © 2020 Publication Centre of Anhui Medical University. All rights reserved.

Research progress on circular RNA vaccines.

Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.

Geographical Studies on Human Trafficking in China: Progress Review and Governance Implications

The crime of human trafficking is an abnormal (involuntary, passive) phenomenon of population migration (disappearance, persecution);it has attracted great attention from the public and academic community because of its resultant social harm and far-reaching impacts on individuals and families. Constrained by the concealment, dispersion, variability, and complexity of the crime of human trafficking in China, the perspectives of earlier research topics were relatively clustered and limited. During the last 10 years, geographers have gradually achieved certain new understandings and progress through continuous exploration. From the perspective of the related sub-disciplines of geography, this study focuses on the main progress, existing issues, future trends, and crime governance paths to review studies on the crime of human trafficking in China. The results indicate the following: (1) Regarding the interdisciplinary situation: The crime of human trafficking is a social pain point of common concern among multiple disciplines. Geography has the advantage of being a latecomer and its integration with other disciplines will help understand the problem in depth and solve it systematically. Geographers will have a broad stage for future research in the field of human trafficking crimes. (2) Regarding the research objects: The earlier studies on the crime of child trafficking in China in the international context were actually subject studies of human trafficking in the Chinese criminal law context. The crime of human trafficking in China is unique compared to other countries and other types of crimes. (3) Regarding the research data: In the past, the data sources mainly comprised non-governmental organizations and individuals. The current data sources show the co-occurrence of non-governmental and official sources and the trend of the integration of offline and online availability. The integration and utilization of multi-source data will be the main path to future studies. (4) Regarding field investigation: In the context of the COVID-19 pandemic's impact and the upgrading of related family tracing means, field investigation has opened up new ways, and online investigations (online interviews, participatory observation in live broadcasting rooms, etc.) have become complementary or alternative channels of traditional field investigations and surveys. (5) Regarding patterns and trends: Based on the update and verification of available data, it is found that the stability of the spatiotemporal pattern of trafficking crimes and the dependence on the main routes in China, and cross-border and inter-provincial border areas, are worthy of attention. Future research trend will shift from being independent to comprehensive—from a quantitative study to a qualitative or mixed study;from case numbers to individuals, families, and their social networks;from the source area to the bridging of source, flow, and sink areas;and from a type of human trafficking to multi-type comparisons of missing persons. (6) Regarding measures and suggestions: Combined with the existing research knowledge and current crime trends, this study presents overall strategies and specific paths for dealing with the crime of human trafficking and assisting the abducted and their relatives. © Starobulgarska Literatura 2022.

[Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2].

As a member of the dibenzyl isoquinoline alkaloid family, cepharathine is an alkaloid from the traditional Chinese medicine cepharathine, which is mainly used for treatment of leukopenia and other diseases. Recent studies of the inhibitory effect of cepharathine against SARS-CoV-2 have attracted widespread attention and aroused heated discussion. As the original discoverer of the anti-SARS-CoV-2 activity of cepharanthine, here we briefly summarize the discovery of cepharanthine and review important progress in relevant studies concerning the discovery and validation of anti-SARS-CoV-2 activity of cepharathine, its antiviral mechanisms and clinical trials of its applications in COVID-19 therapy.

Research Progress of Drug Treatment in Novel Coronavirus Pneumonia.

As of March 10, 2020, more than 100,000 novel coronavirus pneumonia cases have been confirmed globally. With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. The drugs currently being developed are not adequate to deal with this critical situation. In addition to being controlled through effective isolation, we need a rapid response from the healthcare and biotechnology industries to accelerate drug treatment research. By reviewing the currently available literature published at home and abroad, we summarize the current research progress of drug treatment during the epidemic period. At present, the drugs that can be used for treatment mainly include antiviral drugs, antimalarials, glucocorticoids, plasma therapy, biological agents, and traditional Chinese medicine. The effectiveness and safety of drug therapy need to be confirmed by more clinical studies.